Postdoc in Molecular Pharmacology
7 days ago
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen
We are looking for a highly motivated and dynamic postdoc who has a strong profile within molecular pharmacology of G protein-coupled receptors (GPCRs) for a 3-year position commencing December 1st, 2024, or as soon as possible thereafter.
The Postdoc will work in the Molecular Pharmacology group led by Associate Professor Alexander S. Hauser (https://drug.ku.dk/research-sections/pharmaceutical-informatics/pharmacoinformatics/) on an ambitious project funded by the Independent Research Fund Denmark, Sapere Aude entitled: "Pleiotropic effects — from drug targets to drug actions". The overall objective of the project is to characterize the interplay between naturally occurring variations in prominent drug targets and clinical phenotypes for personalized target and treatment selection using pharmacogenomics.
Your job
As a Postdoc, you will be at the forefront of pharmacogenomics research, playing an important role in unraveling the complex relationship between genetic variations and drug responses. Your work will involve the molecular pharmacological characterization of G protein-coupled receptor genetic variants in recombinant cell lines. Utilizing an array of state-of-the-art assays and technologies, you will generate and analyze high-dimensional datasets, offering novel insights into personalized medicine. Part of your role will be to develop and optimize a robust pipeline to efficiently characterize the effects of multiple drugs across diverse genetic variants. This pipeline will serve as a critical tool for the broader scientific community, enabling more accurate predictions of drug efficacy and safety based on genetic profiles.
Profile
We are looking for a highly motivated and enthusiastic scientist with the following competencies and experience:
Essential experience and skills:
- You have a PhD in pharmacology, pharmaceutical sciences or related science
- You are highly experienced in mammalian cell culture
- You are experienced in assay development and molecular pharmacological characterization of membrane receptors
- Demonstrated ability to independently learn new concepts and solve biological problems
- Proficient communication skills and ability to work in interdisciplinary teams
- Excellent English skills written and spoken
Desirable experience and skills:
- Experience in the supervision of students and research personnel
- Experience with large-scale data analysis with scripting languages (e.g Python, R)
- Screening of ligand and/or mutant libraries
- Active interest in profiling of compounds and mutants in the context of personalized medicine
- G protein-coupled receptor pharmacological assay development/optimization
- Experience in the application of FRET- and BRET-based approaches
- Publication in leading journals related to the research project
Place of employment
The place of employment is at the Department of Drug Design and Pharmacology, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment and support postdocs for their next career steps with an ambiguous mentoring program.
Terms of employment
The average weekly working hours are 37 hours per week. The position is a fixed-term position limited to a period of 3 years. The starting date is December 1st 2024 or as soon as possible thereafter.
Salary
Salary, pension and other conditions of employment are set in accordance with the Agreement between the Ministry of Taxation and AC (Danish Confederation of Professional Associations) or other relevant organisation. Currently, the monthly salary starts at 38,570 DKK/approx. 5,170 EUR (April 2024 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.
Application procedure
Your online application must be submitted in English by clicking 'Apply now' below. Furthermore, your application must include the following documents/attachments – all in PDF format:
- Motivated letter of application (max. one page).
- CV incl. education, work/research experience, language skills and other skills relevant for the position.
- A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do.
- List of publications.
Deadline for applications: 27 September 2024, 23.59pm CET
Questions
For further information please contact Associate Professor Alexander S. Hauser; [e-mail alexander.hauser@sund.ku.dk]
University of Copenhagen and Denmark
Founded in 1479, the University of Copenhagen is the oldest university in Denmark. With 37,000 students and 9,000 employees, it is among the largest universities in Scandinavia and one of the highest ranking in Europe. The University consists of six faculties, which cover Health and Medical Sciences, Humanities, Law, Science, Social Sciences and Theology. Read more at www.sund.ku.dk and www.drug.ku.dk.
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