Master Thesis Project: Investigating Cancer-associated Fibroblasts and Cancer Cells in Vitro

1 month ago


Herlev, Herlev Kommune, Denmark Nordic Bioscience Full time
Project Overview

Nordic Bioscience is seeking a highly motivated M.Sc. student to join our oncology team for a master thesis project focused on investigating the interplay between cancer-associated fibroblasts and cancer cells in vitro.

Background

The tumor microenvironment plays a crucial role in cancer progression, and the extracellular matrix (ECM) is a key component that regulates cellular behavior. Cancer-associated fibroblasts (CAFs) are known to promote tumorigenesis by remodeling the ECM and creating a more favorable environment for cancer cells. Understanding how CAFs and cancer cells collaboratively remodel the ECM is essential for developing new therapeutic strategies to target the tumor microenvironment and inhibit cancer progression.

Project Objectives

The primary objective of this master thesis project is to develop a co-culture model of CAFs with cancer cells to investigate matrix remodeling within the tumor microenvironment. Key activities within the project will include:

  • Conducting a comprehensive review of existing studies on CAFs, cancer cells, and ECM remodeling to establish a foundation for the experimental design.
  • Expanding and characterizing cancer cell lines and adapting them to the so-called "Scar-in-a-Jar" cell culture model.
  • Developing and optimizing mono- and co-culture models to measure ECM biomarkers and validate the model.
  • Exploring the effects of different stimulating compounds on CAF-cancer cell interactions and matrix remodeling.
  • Identifying new targets or biomarkers associated with CAF-driven matrix remodeling for further investigation.
Requirements

We are looking for a highly motivated M.Sc. student with a background in biology, biochemistry, biotechnology, or a related field, preferably with previous knowledge in cell biology. The ideal candidate will be able to work as part of a research team, bring a collaborative mindset, and be eager to learn new skills.

About Nordic Bioscience

Nordic Bioscience is a biotechnology company specializing in the discovery, development, and commercialization of biomarkers for various diseases. Our team has more than 25 years of experience in ECM research and biomarker development, and we aim to help patients by developing novel tools to improve patient care and aid drug development.



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