Senior Data Scientist
3 weeks ago
About the Role
We are seeking a highly skilled Senior Data Scientist to join our Antibody Design Department at Novo Nordisk. As a key member of our team, you will be responsible for developing innovative computational tools and techniques to design novel antibodies and VHHs.
Key Responsibilities
- Collaborate with laboratory scientists to optimize workflows that integrate bulk and single B cell sequencing from in vivo immunization with in vitro antibody and VHH library design.
- Drive creative solutions to design novel antibodies or VHHs in collaboration with other departments, while supporting research projects within the antibody and VHH area.
- Identify potential liabilities and developability issues throughout the antibody discovery pipeline.
- Coordinate the development of the relevant computational infrastructure for ingesting, analyzing, and exposing the information from sequencing and other data sources.
- Utilize existing tools or develop new ones to design and engineer antibody variants with enhanced functionality.
- Integrate experimental results with computational models to expedite the antibody discovery process.
- Work collaboratively with colleagues to develop machine learning models that can be used to optimize antibody candidates.
- Stay up to date with the latest developments in computational biology and antibody/VHH design.
- Document and effectively communicate the discovery and innovation process to key stakeholders and managers.
- Encourage, propose, and participate in projects boosting the use of advanced computational techniques for antibody and VHH design.
Requirements
- Master's degree within Computational Biology, Bioinformatics, Machine Learning, or a related field.
- At least 3+ years of experience in clinical or industrial antibody/VHH development.
- Deep understanding of antibody or VHH sequence, structure, function, and their development in an industrial setting.
- Previous knowledge of NGS sequencing analysis and preferably RepSeq, antibody sequencing, or TCR sequencing.
- Solid experience with relevant computational tools, including but not limited to Python programming, molecular modelling and simulations, sequence analysis, and data analysis frameworks.
- Experience in usage of HPC solutions (AWS, Azure, or similar).
- Full proficiency in English, with knowledge of Danish being a plus.
About the Department
The Antibody Design Department is part of the Digital Science and Innovation (DSI) area at Novo Nordisk, located in Måløv (Denmark) and London (UK). We use innovative computational tools and techniques to design novel antibodies and VHHs. Our team works collaboratively across various departments, within and outside Research and Early Development, to deliver safe and effective antibody therapies to patients.
Working at Novo Nordisk
We are a dynamic company in an even more dynamic industry, and we know that what got us to where we are today is not necessarily what will make us successful in the future. We embrace the spirit of experimentation and strive for excellence without fixating on perfection. We never shy away from opportunities to develop; we seize them. Working at Novo Nordisk means working towards something greater than ourselves, and it's a collective effort. Novo Nordisk relies on the collective potential and collaboration of its employees to make life better for millions of patients living with diabetes and other chronic diseases.
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