Postdoc in Genetic Regulation of the Plasma Proteome and its Link to Cardiometabolic Disease in

4 days ago

Copenhagen, Copenhagen, Denmark Københavns Universitet Full time

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Postdoc in Genetic Regulation of the Plasma Proteome and its Link to Cardiometabolic Disease in Greenlandic Inuit

Novo Nordisk Foundation Center for Basic Metabolic Research
Faculty of Health and Medical Sciences
University of Copenhagen

The University of Copenhagen is seeking a highly motivated and talented Postdoc fellow to commence on February 1, 2025, or after agreement in the Hansen Group at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), University of Copenhagen.

About Us
The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) is an academic research Center that pioneers groundbreaking research towards better cardiometabolic health. Through collaborative interdisciplinary research from single-cell genomics to whole-body systems, CBMR aims to transform the basic understanding of cardiometabolic health and accelerate its translation into prevention and treatment strategies. The Center's uniquely multi- and interdisciplinary approach combines research in genetics, physiology and pharmacology, to better understand the complex interplay of the many factors that drive cardiometabolic disease.

Our Research
In the molecular understanding of metabolic diseases, a major gap exists between basic genetic and microbiome discoveries and their impact on physiology and the potential for clinical translation. The Hansen Group aims to bridge this gap by connecting genomic discoveries and epidemiology, with physiology and clinical application. To study the role of selected genetic variants in human metabolism, we perform physiology and intervention studies based on recruit-by-genotype principles.

Job Description
Genome-wide association studies (GWAS) have laid the framework for understanding the impact of genetic variation on complex disease risk, predominantly identifying common variants with small effects. Studying isolated populations has the power to enhance the discovery of disease-associated loci, due to the enrichment of certain rare variants with large effects. Circulating proteins provide deep insights into the current state of human health and can capture the influence of environment on disease pathogenesis. The Postdoc will work on a project that will integrate high-throughput mass spectrometry (MS)-based plasma proteomics data with electronic health registry data, along with genetic information from 4,180 Greenlandic individuals to drive the discovery of novel clinical biomarkers and therapeutic targets which may aid in the future prevention and treatment of cardiometabolic diseases, including obesity, type 2 diabetes (T2D), and cardiovascular diseases (CVDs).

Your tasks will be to:

  • Examine baseline and longitudinal associations between the MS-based plasma proteome and cardiometabolic disease outcomes using registry-based data.
  • Perform a GWAS of the MS-based plasma proteome to identify protein quantitative trait loci (pQTLs).
  • Examine the overlap between pQTLs and cardiometabolic disease-associated risk variants using colocalization methods.
  • Coordinate project-related tasks.
  • Contribute to scientific papers.

Profile
The Postdoc fellowship is aimed at early-career researchers with a background in data science or bioinformatics and familiar with integrative research approaches within the broad area of basic cardiometabolic research.

Required qualifications:

  • PhD in bioinformatics, computational biology, statistical genomics or similar.
  • Proficiency in a high-level programming language such as R or Python.
  • Experience in applying statistical methods to proteomic and/or genomic data.
  • Experience from working with large genomic datasets.
  • Proven track record showing scientific productivity in peer-reviewed journals.
  • Excellent English communication skills, both written and oral.

Eligibility
The Postdoc fellowships within the CBMR International PhD & Postdoc Program are open for applicants that hold a PhD degree awarded from a university outside of Denmark. The program is also open for applicants with a Danish PhD degree who can document at least 12 months of full-time research experience from outside Denmark during or after the PhD studies. The PhD degree has to be obtained before February 1, 2025.

Terms of Employment
The employment as Postdoc is a full-time position for 3 years. Starting date is February 1, 2025, or after agreement.

Application Procedure
Your online application must be submitted in English via the 'Apply now' link below. Furthermore, your application must include the following documents/attachments – all in PDF format:

  • Cover letter expressing the motivation and previous research experience of the applicant (max. one page)
  • Copy of the PhD degree certificate and the master's degree certificate. In case the PhD has not yet been completed, a written statement from the supervisor is acceptable, confirming it will be obtained before February 1, 2025.
  • List of publications
  • References (name and contact details of at least two references)

Application Deadline: September 20, 2024, 23.59pm CET.

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of their personal backgrounds.

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