Senior Researcher in Ribosome Specialization
2 days ago
Ribosome Specialization
Ribosomes are the cellular machinery responsible for protein synthesis. In humans, ribosomes play a central role in many biological processes, including cell growth, differentiation, and survival. However, aberrant ribosome function has been implicated in various diseases, including cancer.
Our Research Focus
Our group focuses on understanding how ribosome specialization contributes to translational programs and how these processes are hijacked in human disease. We use a variety of model systems, including human stem cells, neuronal cultures, and 2D and 3D cultures of human cells and patient samples.
Methodology
We employ a range of experimental approaches, including ribosome profiling, RiboMeth-seq, and mass spectrometry, to investigate the mechanisms underlying ribosome specialization and its contribution to human disease.
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