PhD Researcher in Mass Spectrometry for Single-Cell Proteomics

2 days ago


Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

**About the Project**

The Cell Diversity Lab at DTU Bioengineering invites applications for a 3-year PhD scholarship in developing novel single-cell proteomics sample preparation techniques.

This PhD project is part of the department's major long-term strategy to combine experimental and computational approaches to establish scp-MS as a routine tool for deciphering cell heterogeneity in complex biological systems.

The successful candidate will be working on developing novel sample preparation methods, including enrichment of Post-Translational Modifications, for conducting high-throughput scp-MS experiments.

Key Responsibilities:

  • Develop low-volume liquid handling approaches to enhance sensitivity for scp-MS.
  • Explore novel chromatography approaches to enhance sensitivity for scp-MS.
  • Use a range of mass spectrometry data acquisition strategies to explore their application in low-input proteomics all the way down to single cells.

About the Group

The Cell Diversity Lab is focused on development and application of cutting-edge LC-MS technologies. The group aims to unravel fundamental biological concepts controlling heterogeneity within complex biological systems, especially those of the blood system and cancer.

**Requirements:**

  • Master's degree in biochemistry, biomedicine, medicinal chemistry, molecular biology, immunology or related subjects.
  • Advanced understanding of Mass Spectrometry-based proteomics workflows.
  • Track record in single-cell proteomics method development.

For more information about the position, please contact Associate Professor Erwin Schoof at DTU Bioengineering.



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