Principal Scientist, In vitro Drug-Drug interaction studies

3 days ago

Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

Requisition ID: 6182

Location:

Copenhagen, Danish Capital Region, DK

Principal Scientist for in vitro Drug-Drug interaction studies in the Department of Drug Metabolism

Do you have a passion for in vitro Drug-Drug interaction (DDI) studies and like to develop PBPK models to evaluate the DDI risk in humans? Do you thrive with scientific challenges? Then you may be our new colleague.

Your new role

You will be responsible for evaluating the DDI risk of Lundbeck development compounds, which includes close collaboration with our colleagues in Clinical Pharmacology. As a part of your job, you will also be responsible for the planning, conducting and reporting of in vitro DDI studies as well as PBPK modelling and simulation. Thus, you will be managing studies such as enzyme reaction phenotyping, enzyme inhibition, enzyme induction, transporter inhibition, transporter substrate evaluations as well as mechanistic studies. As an important part of your work, you will work in close collaboration with Contract Research Organisations (CROs), who are performing studies on behalf of Lundbeck. Furthermore, you will be responsible for studies performed in our laboratories and in that role be sparring and guiding our technicians. Moreover, you will represent the DDI group in project teams ensuring progress of our innovative and promising pipeline. In addition, you will be driving the science within the DDI group together with your colleagues.

Your future team

The Department of Drug Metabolism is part of the Drug ADME Research Division within Non-Clinical Safety Research. Non-Clinical Safety Research is responsible for the safety evaluation of novel drug candidates for the treatment of diseases within the central nervous system. The Department of Drug Metabolism is responsible for providing non-clinical and human ADME data, and data on drug-drug interaction potential for worldwide registration of new innovative medicines. We are a group of 13 scientists and technicians in total divided into two teams (Drug-drug interaction and Metabolism). Our team is based in Valby, Copenhagen, and we pride ourselves on fostering scientific excellence, a collaborative, supportive, and friendly work environment. We believe in open communication, continuous learning, and celebrating our successes together.

What you bring to the team

Our preferred candidate:

  • Holds a PhD in biochemistry, pharmacy, chemical engineering or equivalent
  • Has experience within and thorough understanding of enzymology of major drug metabolizing enzymes, inhibition kinetics and design of in vitro DDI studies
  • Has experience within and thorough understanding of drug transporters
  • Has hands-on experience with in vitro DDI assays and experience with LC-MS
  • Experience with PBPK modelling and simulations would be an advantage
  • Has experience with DDI guidelines and preparation of regulatory summary documents (i.e. IB, IND, CTD)
  • Experience from pharmaceutical industry
  • Has focus on delivering high quality data in due time and is result-oriented
  • Is enthusiastic, ambitious, proactive and a true team player
  • Has good communication skills and is fluent in English.

Our promise to you

Lundbeck offers an inspiring workplace and innovative culture, where our curiosity, accountability and adaptability enable us to transform lives. We want to go faster and further on addressing the big unmet needs of people living with brain disorders. We offer rewarding careers with a mix of exciting tasks and development opportunities that are balanced with initiatives focused on your well-being.

Can you see yourself in this role? We want to hear from you. Does this sound like your dream job, but you're not sure if you meet all the requirements? We still want to hear from you

Upload your CV and include a few lines about your motivation for applying. No separate cover letter is needed. We ask you not to include a photo or personal information that does not relate to your professional experience.

If you have questions or want to hear more, please feel free to contact Mette G. Hvenegaard, Director, tlf. 30833174. Applications must be received by April 6th 2025 .

We need every brain in the game – and that includes all brains and the different perspectives we bring to the table. At Lundbeck, we embrace the uniqueness of each employee, and we are committed to building a workforce that is as diverse as the people we serve.

This job ad is intended for individuals seeking a career opportunity with Lundbeck. We engage with recruitment and search firms where needed on the basis of a written agreement, and we do not accept unsolicited requests of any kind. If you work as a recruitment consultant, you are kindly instructed to refrain from contacting Lundbeck or the hiring manager directly with suggested candidates. If you violate this policy, you do so at your own risk and for your own account, and Lundbeck will not assume any liability nor pay any associated fees resulting from such violation.

#J-18808-Ljbffr

  • Scientific Leader for In Vitro Drug-Drug Interaction Studies

    3 days ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    At Lundbeck A/S, H, we are seeking a highly skilled Scientific Leader to join our Department of Drug Metabolism. As Principal Scientist, you will be responsible for evaluating the drug-drug interaction (DDI) risk of Lundbeck development compounds. This involves close collaboration with colleagues in Clinical Pharmacology and managing studies such as enzyme...

  • Principal Research Scientist for ADME and DDI

    2 days ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    Lundbeck A/S, H is seeking a Principal Research Scientist for ADME and DDI to join our Department of Drug Metabolism. The successful candidate will be responsible for evaluating the DDI risk of Lundbeck development compounds, including close collaboration with colleagues in Clinical Pharmacology and managing studies such as enzyme reaction phenotyping,...

  • Principal Scientist, Translational DMPK

    5 days ago

    Copenhagen, Copenhagen, Denmark H. Lundbeck AS Full time

    Do you have experience as DMPK project representative within large molecule drug discovery projects? Then you might just be the new colleague that we are looking for. We have an opening for a Principal Scientist to join Translational DMPK. The department is part of the dynamic Research organization at Lundbeck located in Copenhagen. Your new role – why is...

  • Biotech Research Scientist

    5 days ago

    Copenhagen, Copenhagen, Denmark The Biopôle Full time

    Opportunity Summary:We are seeking an experienced in vitro biologist to join our team at Orbis Medicines, where you will contribute to the discovery and development of innovative therapeutics.As a member of our team, you will have the opportunity to apply your scientific expertise to shape the future of drug discovery, collaborating with cross-functional...

  • In Vitro Toxicology Specialist Lead

    11 hours ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    Toxicological Support for Innovative Drug ResearchLundbeck A/S, H invites applications for a Toxicology Scientist/Specialist position in our Department of Exploratory Toxicology.This role involves providing toxicological support to all drug research projects at Lundbeck, from target discovery to drug candidate selection. As a member of our team, you will...

  • In Vitro Toxicology Expert

    13 hours ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    At Lundbeck A/S, H, we are committed to delivering innovative solutions that bring hope to patients and their families. We have an exciting opportunity for a talented In Vitro Toxicology Scientist/Specialist to join our team in the Department of Exploratory Toxicology.About the RoleWe are seeking a highly skilled scientist with a strong background in in...

  • In vitro Toxicology Scientist/Specialist- Department of Exploratory Toxicology

    16 hours ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    In vitro Toxicology Scientist/Specialist - Department of Exploratory Toxicology Requisition ID: 5584 Location: Copenhagen, Danish Capital Region, DK In vitro Toxicology Scientist/Specialist – Department of Exploratory Toxicology As a new colleague in the Department of Exploratory Toxicology, you will join a team of experts who provide toxicological...

  • In vitro Toxicology Scientist/Specialist- Department of Exploratory Toxicology

    15 hours ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    In vitro Toxicology Scientist/Specialist - Department of Exploratory ToxicologyRequisition ID: 5584Location: Copenhagen, Danish Capital Region, DKIn vitro Toxicology Scientist/Specialist – Department of Exploratory ToxicologyAs a new colleague in the Department of Exploratory Toxicology, you will join a team of experts who provide toxicological support to...

  • Medicinal Chemist

    4 days ago

    Copenhagen, Copenhagen, Denmark The Biopôle Full time

    About The Biopôle">The Biopôle is a pioneering biotech company dedicated to the future of drug discovery through cutting-edge chemistry and data-driven approaches. We are committed to transforming the treatment landscape by discovering and developing innovative therapeutics.As a member of our team, you will contribute to the discovery and development of...

  • In Vitro Biology Expert

    4 days ago

    Copenhagen, Copenhagen, Denmark The Biopôle Full time

    About the Role">This is an exciting opportunity to join our team as a Biomedical Research Leader. As a senior bioprocess research scientist, you will be responsible for designing and synthesizing macrocycle projects, establishing workflows, and driving cross-functional collaborations.Your primary focus will be on developing in vitro / ex vivo assays to...

  • In Vitro Toxicology Scientist/Specialist Position

    4 days ago

    Copenhagen, Copenhagen, Denmark H. Lundbeck AS Full time

    Lundbeck's Department of Exploratory Toxicology is seeking an expert in predictive in vitro cell assays to join our team. As a new colleague, you will play a key role in evaluating mechanisms and risks of toxicity for new drug candidates.Our team uses a combination of in-house in vitro and in vivo methods, as well as in silico tools when appropriate. You...

  • Senior Scientist Drug Product Analysis and Stability

    16 hours ago

    Copenhagen, Copenhagen, Denmark LEO Pharma Full time

    Select how often (in days) to receive an alert: Senior Scientist Drug Product Analysis and Stability Field of work: Research Posting Date: 27 Jan 2025 Would you like to engage in complex projects that challenge your skills and expand your expertise in analytical chemistry and pharmaceutical science, and be part of a professional environment that values...

  • Research Expert in Pharmacokinetics and Toxicology

    2 days ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    Join our team at Lundbeck A/S, H, where we are dedicated to transforming lives by developing innovative medicines for brain disorders. We are seeking a Research Expert in Pharmacokinetics and Toxicology to join our Department of Drug Metabolism.In this role, you will be responsible for evaluating the drug-drug interaction (DDI) risk of Lundbeck development...

  • Drug Product Development Expert

    7 days ago

    Copenhagen, Copenhagen, Denmark Novo Nordisk AS Full time

    Job Description Overview">We are seeking an experienced Drug Product Manager to join our Product Life Cycle Management II team. As a Drug Product Manager, you will be responsible for the quality of our marketed Rare Diseases Products.">Main Responsibilities">Oversee all aspects of drug product development, from concept to launch.Collaborate with...

  • Scientist for Predictive Toxicology

    5 hours ago

    Copenhagen, Copenhagen, Denmark Lundbeck AS, H Full time

    We are seeking an In Vitro Toxicology Scientist/Specialist to join our Department of Exploratory Toxicology at Lundbeck A/S, H. As a key member of our team, you will be responsible for designing, developing, and optimizing predictive in vitro cell assays for screening for toxicity/organ-specific toxicity of new compounds.About the RoleYou will work closely...

  • Drug Product Manager

    1 week ago

    Copenhagen, Copenhagen, Denmark Novo Nordisk AS Full time

    Are you passionate about ensuring drug product quality throughout its lifecycle? Would you like to be part of a dynamic department responsible for our marketed Rare Diseases Products? Ready to collaborate across teams and drive optimization? We are looking for a new colleague to join us as a Drug Product Manager. Apply now for a life-changing career The...

  • Senior Research Scientist, Biologics PK

    5 days ago

    Copenhagen, Copenhagen, Denmark H. Lundbeck AS Full time

    At H. Lundbeck A/S, we are seeking a Senior Research Scientist to join our Translational DMPK department in Copenhagen.We have an opening for a Principal Scientist to contribute to the optimization and characterization of new compounds in our discovery programs.In this role, you will be involved in guiding the DMPK optimization process, closely interacting...

  • In vitro Toxicology Scientist/Specialist- Department of Exploratory Toxicology

    5 days ago

    Copenhagen, Copenhagen, Denmark H. Lundbeck AS Full time

    In vitro Toxicology Scientist/Specialist– Department of Exploratory Toxicology As a new colleague in the Department of Exploratory Toxicology, you will join a team of experts who provide toxicological support to all drug research projects at Lundbeck, from the earliest inception of innovative targets to drug candidate selection. Our main task is to...

  • In vitro Toxicology Scientist/Specialist- Department of Exploratory Toxicology

    3 days ago

    Copenhagen, Copenhagen, Denmark H. Lundbeck AS Full time

    In vitro Toxicology Scientist/Specialist– Department of Exploratory Toxicology As a new colleague in the Department of Exploratory Toxicology, you will join a team of experts who provide toxicological support to all drug research projects at Lundbeck, from the earliest inception of innovative targets to drug candidate selection. Our main task is to...

  • Senior Bioprocess Research Scientist

    4 days ago

    Copenhagen, Copenhagen, Denmark The Biopôle Full time

    Role Overview">We are seeking a highly skilled Senior Bioprocess Research Scientist to join our team at The Biopôle. As a Medicinal Chemist, you will be responsible for leading the design and synthesis of macrocycle projects, establishing workflows, and driving cross-functional collaborations.Your primary focus will be on developing in vitro / ex vivo...