Innovative ECM Researcher: Uncover Cancer Cell Dynamics

3 weeks ago


Herlev, Herlev Kommune, Denmark Nordic Bioscience Full time

Are you driven by a passion for understanding the intricate mechanisms of cancer cell behavior in the tumor microenvironment? Do you want to contribute to the development of novel biomarkers and therapeutic strategies to combat cancer progression?

Nordic Bioscience, a leading biotechnology company with over 25 years of experience in ECM research, is seeking a highly motivated M.Sc. student to join our oncology team as an Innovative ECM Researcher.

This master thesis project focuses on developing a co-culture model of cancer-associated fibroblasts (CAFs) with cancer cells to investigate matrix remodeling within the TME. The primary objective is to examine how the interaction between CAFs and cancer cell lines influences the production and cleavage of collagen matrices.

The project will involve:

  • Literature Review: Conduct a comprehensive review of existing studies on CAFs, cancer cells, and ECM remodeling to establish a foundation for the experimental design.
  • Expansion and Characterization of Cancer Cells: Expand cancer cell lines and adapt them to the so-called 'Scar-in-a-Jar' cell culture model. Measure different ECM biomarkers in the cell supernatant.
  • Development and Optimization of Mono- and Co-Culture Models: Identify the best conditions for mono- and co-culture, followed by the measurement of ECM biomarkers and validation of the model.
  • Stimulation with Various Compounds: Explore the effects of different stimulating compounds on CAF-cancer cell interactions and matrix remodeling.
  • Identification of New Targets and Biomarkers: Based on the experimental outcomes, potential new targets or biomarkers associated with CAF-driven matrix remodeling will be identified for further investigation.

As an Innovative ECM Researcher at Nordic Bioscience, you will have the opportunity to work closely with our experienced research team, leveraging your skills in biology, biochemistry, or related fields to drive cutting-edge research. Your contributions will help us develop innovative solutions to address the complexities of cancer progression.

To succeed in this role, you should possess:

  • A strong background in biology, biochemistry, or related fields.
  • Excellent communication and teamwork skills.
  • Ability to work independently and collaboratively as part of a research team.

We offer a competitive salary ranging from $55,000 to $65,000 annually, commensurate with experience, along with opportunities for professional growth and development in a dynamic research environment. Join us in shaping the future of cancer research and making a meaningful impact on patient care.



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