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Urine Peptide-Based Classifiers for CKD Understanding
1 month ago
This is a 3-year PhD position as part of the European Doctoral Network (DN) program entitled "Personalized Medicine in Chronic Kidney Disease (PICKED)". The PhD position is hosted at Steno Diabetes Center Copenhagen, Denmark.
The PICKED ConsortiumKidney diseases, both chronic (CKD) and acute (AKI), are a priority and a challenge for Public Health Policies, affecting > 850 million persons worldwide. The major urgent needs include early detection in "at-risk" patients of CKD, detection and prediction of CKD progression/complications, and personalized treatment avoiding over- or unnecessary-treatment. To address these challenges, it is essential to train professionals to identify these issues.
Objectives of the PhDThe overall objective of the PhD project is to investigate urinary peptide patterns and the effect of different contemporary treatments to increase understanding of specific beneficial pathways that treatments affect and explore kidney-specific mechanisms through which these compounds act.
Key Responsibilities- Collect existing data from cohorts with renal follow-up to expand previous analyses and perform detailed exploration of available data.
- Measure urinary proteomics patterns in stored samples from intervention trials with SGLT2 inhibitors and GLP-receptor agonists to understand at least part of the mechanism behind the renal benefit seen with these drugs.
- Explore performance of recently developed classifiers in the collected cohorts with urinary proteomic data available.
You will be enrolled in a PhD programme at the Copenhagen University and supervised by Peter Rossing and Tine Willum Hansen from Steno Diabetes Center Copenhagen and Paul Perco from University of Heidelberg.
Required Skills and Education- You hold a master's degree in medicine.
- You speak and write fluent English. As discussion with people with CKD is part of the project, some Danish skill is an advantage.
- You are ambitious, well organized, and have excellent communication skills.
- You have the ability to work effectively and collaboratively.
- You are an enthusiastic and motivated person, ready to participate in personal training, international travel, and public awareness activities.
- You must not have a doctoral degree at the date of your recruitment.
- You must comply with the mobility rule: not have resided or carried out your main activity (work, studies, etc.) in Denmark for more than 12 months in the 36 months immediately before the recruitment date.
- You will benefit from all Marie Skłodowska-Curie Action scheme advantages.
- You will participate in the weekly web-seminars (in English) of the collaborative network of the laboratory including 20 laboratories.
- You will attend yearly meetings organized by the PICKED consortium, as well as international and national congress.
