PhD fellowship in Microglassification of proteins at Department of Pharmacy
1 month ago
Faculty of Health and Medical Sciences, University of Copenhagen
We are offering a three-year PhD fellowship in microglassification of pharmaceutical proteins commencing 15th of March 2025 or as soon as possible thereafter.
Protein drugs have allowed for a safer and more effective treatment of various severe diseases, such as diabetes and cancer. However, proteins generally need to be administered by injection, and due to their instability in solution, they are often prepared in a dried formulation that requires rehydration before administration. In this project, we plan to investigate a novel method, termed microglassification, to prepare dried protein particles with desired properties. Using microfluidics, the various factors that govern particle characteristics like size and protein structural integrity will be investigated in detail, allowing a rational design of these particles for specific purposes. For example, these protein particles may be used in injectable suspensions, for pulmonary delivery, or in solid dosage formulations for oral delivery. The impact of various excipients on particle properties will be investigated, with a special focus on protein structural integrity. In vitro properties of these particles can then be studied, with a possible follow-up of in vivo studies to determine their performance in a real-life setting.
This interdisciplinary project thus involves particle design, protein biophysics and advanced analytical characterization, physical chemistry, and may ultimately include in vivo efficacy studies.
Start
15th of March, 2025
Duration
3 years as a PhD student
Job Description
Your key tasks as a PhD student at the Faculty of Health and Medical Sciences are:
- Carrying through an independent research project under supervision
- Completing PhD courses or other equivalent education corresponding to approximately 30 ECTS points
- Participating in active research environments including a stay at another research team, preferably abroad
- Obtaining experience with teaching or other types of dissemination related to your PhD project
- Teaching undergraduate students in pharmaceutical sciences
- Writing a PhD thesis based on your project
Key Criteria for the Assessment of Applicants
Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project, e.g., pharmaceutical sciences, physical chemistry, engineering, or similar. Please note that your master’s degree must be equivalent to a Danish master’s degree (two years).
Other important criteria are:
- Professional qualifications relevant to the PhD project
- The grade point average achieved
- Other professional activities
- A curious mindset with a strong interest in protein biophysics and pharmaceutical technology
Preferred Qualifications
Beyond the requirements listed above, we are looking for a highly self-motivated individual with experience in and/or knowledge of drug delivery of biopharmaceuticals, protein structural analysis, microfluidics, and/or physical chemistry. The candidate must be able to work independently but will interact with a multidisciplinary project group involved in many aspects of studying and evaluating protein drug delivery. Extensive training in the relevant disciplines will be provided.
Place of Employment
The place of employment is at the Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a range of biophysical methods to study protein structure and instability, as well as microfluidics expertise and small-animal facilities.
Terms of Employment
The average weekly working hours are 37 hours per week. The position is a fixed-term position limited to a period of 3 years. The employment is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project to the Graduate School of Health and Medical Sciences.
The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree.
Salary, pension, and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary starts at approximately 30,716 DKK/Roughly 4,095 EUR (April 2024 level) plus pension.
Application Procedure
Your application, in English, must be submitted electronically by clicking “Apply now” below and must include the following documents in PDF format:
- Motivated letter of application (max. one page)
- CV incl. education, experience, language skills, and other skills relevant for the position
- Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish.
- Other information to consider: References and recommendations (if possible)
The deadline for applications is 5 December 2024, 23:59pm CET
We reserve the right not to consider material received after the deadline, and not to consider applications that do not meet the abovementioned requirements.
The Further Process
After the expiry of the deadline for applications, the authorised recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.
Interviews are expected to be held in week 4 (January 20-24, 2025).
The University of Copenhagen wishes to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.
InfoEmployment Start: 15-03-2025
Working Hours: Full time
Department/Location: Department of Pharmacy
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