Postdoc in Therapeutic Engineering of iPSC-NK cells

1 day ago


Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark DTU - Technical University of Denmark Full time

A 2.5-year position for an experienced postdoc is available within the research group 'Biotherapeutic Glycoengineering and Immunology' headed by Professor Steffen Goletz and is funded by the DigitSTEM initiative. Our research group belongs to the Section of Medical Biotechnology at the Department of Biotechnology and Biomedicine.

In our research group, we apply and develop advanced next generation antibody engineering as well as cellular and molecular glycoengineering technologies to elucidate the role of glycosylation's within complex immunological networks and disease and to generate novel therapeutic approaches and drug candidates. Our main therapeutic interest is within immuno-oncology as well as infectious and lung diseases. One focus lies within cellular engineering and glycoengineering of human innate immune cells using gene editing for highly effective cell-based immunotherapeutics and the design and development of their manufacturing processes. Further focus areas are within next generation antibody engineering with bi-/ multi-specific and multimodal antibodies, phage display technologies, exosome engineering and drug delivery, gene therapy, NK- and DC- cell based therapies and their mammalian bioprocess engineering and manufacturing. We also have a strong focus on innovation and entrepreneurship.

The DigitSTEM initiative is a four-year stem cell focused research collaboration between The Technical University of Denmark (DTU), the The Novo Nordisk Foundation Center for Stem Cell Medicine (renew) at University of Copenhagen, and Bioneer A/S that aims at developing new in vitro disease models and therapeutics using human pluripotent stem cells (hPSCs).

The current position focuses on engineering, glycoengineering and differentiation of human induced-pluripotent stem cells (iPSCs) into NK-cells, inducible gene-editing, exosome-based gene editing and bridging activities to our AI-assisted manufacturing approach.

Responsibilities and qualifications
You as the postdoc will work with a team of Senior scientists, postdocs, and PhD students and in close collaboration with academic and industrial collaborators within the DigitSTEM initiative to establish a novel iPSC-derived NK-cell platform for next generation biotherapeutics.

You as the postdoc candidate for this challenging project are highly motivated and must be extensively trained and experienced with a track record in human cell engineering and gene editing, NK cell therapeutics and NK-cell biology, cellular immunology and assay technologies, in vitro 2D- and 3D cancer models, as well as immunooncology in differentiation of NK cells from human iPSCs and within NK-cell biology and assay systems. A prior postdoc in this field is advantageous. Knowledge and skills in stem cell engineering, inducible gene editing technologies, differentiation of NK-cells from iPSC, exosome based gene delivery, antibody and single-domain antibody engineering and discovery, mammalian cell manufacturing, cell-line development, and, glycoengineering, glycoanalytics, and big data analysis will be of great advantage. Moreover, you as the postdoc is expected to contribute to inter connective team tasks as well as in teaching and supervision of PhD, BSc, and MSc students.

You must hold a PhD degree in a relevant life-science discipline (cellular engineering, NK cell or stem cell biology, immunology, immunooncology or alike), have excellent communication skills and be extensively trained in immunology, stem cell biology, cellular engineering, cell culture systems, and computational data analysis.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2.5 years.

Starting date is 1st May 2025 (or according to mutual agreement). The position is a full-time position.

Application procedure
Your complete online application must be submitted no later than 30 March 2025 (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file . The file must include:

  1. Application (cover letter)
  2. CV
  3. Academic Diplomas (MSc/PhD – in English)
  4. List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

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