Postdoc in Stem Cell Biology and Neurodegenerative Disease Modeling

2 days ago

Kongens Lyngby, Denmark DTU - Technical University of Denmark Full time

Do you have a passion for stem cell biology and neurodegenerative disease modeling, and are eager to contribute to breakthrough research? If you have extensive experience with pluripotent stem cells, cellular differentiation, and cellular pathology in neurodegenerative conditions, you might be the candidate we are looking for.

The overarching goal of this project is to drive advancements in genetic medicine through the development of innovative models for screening genetic mutations in iPSC-derived cells. Additionally, you will contribute to establishing cutting-edge model systems that enable rapid evaluation of novel genetic therapies.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) at the Technical University of Denmark invites applications for a postdoctoral position in the field of Stem Cell Biology and Neurodegenerative Disease Modeling. In this role, you will join a multidisciplinary research team dedicated to advancing the understanding of cellular mechanisms underlying neurodegenerative diseases, as well as exploring innovative differentiation protocols for pluripotent stem cells.

Responsibilities

  • Conduct advanced research focused on the differentiation of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) into microglia and other defined cell types.
  • Optimize and benchmark culture conditions and differentiation protocols for hESC and iPSC lines.
  • Employ techniques such as qPCR, high-throughput cell profiling, mass spectrometry, and flow cytometry to analyze cellular and molecular outcomes.
  • Investigate early molecular changes in neurodegenerative disease models.
  • Collaborate on interdisciplinary projects involving single-cell sequencing, transcriptomics, and proteomics data analysis.
  • Contribute to student supervision and engage in course teaching.
  • Present findings at scientific conferences and in scientific publications.

Qualifications

  • PhD in a relevant field (e.g., Molecular Biology, Biomedical Science, Stem Cell Biology).
  • Expertise in culturing, maintaining, and differentiating hESCs and iPSCs, including proficiency in embryoid body formation, macrophage precursor factory maintenance, and microglia differentiation.
  • Strong experience in cellular neurodegenerative disease modeling, especially with Parkinson’s disease cellular models.
  • Proficiency in standard molecular biology and biochemistry techniques, including qPCR, RNA and DNA isolation, FACS analysis, and immunocytochemistry.
  • Hands-on experience with high-throughput profiling and data preparation for single-cell sequencing (10X Genomics) and mass spectrometry.
  • Demonstrated ability in data analysis of multi-omic datasets (scRNA-seq, ChIP-seq) using bioinformatics tools (e.g., R, Python, and Shell scripting).
  • Experience with confocal microscopy, fluorescence microscopy, and image analysis software.

We seek a highly motivated and independent researcher with a track record of scientific excellence and a collaborative spirit.

If you are driven by innovative research and excited to advance the field of stem cell biology and to develop cutting-edge model systems, we encourage you to apply.

You must contribute to the teaching of courses. DTU employs two working languages: Danish and English. You are expected to be fluent in at least one of these languages, and in time are expected to master both.

As a formal qualification, you must hold a PhD degree (or equivalent).

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 1.5 years. Starting date is February 1, 2025. The position is a full-time position.

Application procedure
Your complete online application must be submitted no later than 20 January 2025 (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file . The file must include:

  • Application (cover letter)
  • CV
  • Academic Diplomas (MSc/PhD – in English)
  • List of publications.

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

#J-18808-Ljbffr

  • Postdoc in lung-to-brain mast cell regulation in asthma

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    We seek a postdoc with expertise in mast cells and/or allergic immune regulation to join our mission to improve the lives of individuals experiencing brain fog in airway allergy and asthma. Are you the next pioneer in the immunology of airway allergy and asthma? We are seeking a curious, talented and pro-active postdoc with a background in immunology,...

  • Unlock the Secrets of Single-Cell Proteomics as a PhD Researcher

    1 month ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    At DTU Bioengineering, we're pushing the boundaries of single-cell proteomics and Mass Spectrometry (scp-MS) to uncover fundamental biological concepts controlling heterogeneity within complex biological systems. As a PhD researcher, you'll be part of our mission to unravel druggable signalling mechanisms that advance therapy and diagnostics for patients...

  • PhD scholarship in developing novel single-cell proteomics sample preparation techniques

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Are you fascinated with pushing the envelope of what is technologically possible in single-cell proteomics? The Cell Diversity Lab has a 3-year method development PhD position available, embedded within a group focused on development and application of cutting-edge LC-MS technologies. If you are establishing your career as a scientist and are looking for a...

  • PhD Position in Single-Cell Proteomics Method Development

    2 weeks ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    At Danmarks Tekniske Universitet (DTU) Bioengineering, we are seeking a highly motivated and skilled PhD candidate to join our Cell Diversity Lab team. Our mission is to unravel fundamental biological concepts controlling heterogeneity within complex biological systems, especially those of the blood system and cancer.We are looking for an individual with a...

  • Red Blood Cell Substitute Researcher – Biomedical Innovation

    2 weeks ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Company OverviewDanmarks Tekniske Universitet (DTU) is a leading technical university globally recognized for excellence in research, education, innovation, and scientific advice.Job DescriptionWe are seeking a highly motivated postdoctoral researcher to join our team at the Biomimetics, Biocarriers, and Bioimplants Group. The successful candidate will be...

  • Breakthrough in Single-Cell Proteomics: PhD Scholarship Opportunity

    2 months ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Company OverviewDanmarks Tekniske Universitet (DTU), a leading technical university globally recognized for its excellence in research, education, innovation, and scientific advice.Salary and BenefitsThe appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the...

  • Research Scientist in Lung-To-Brain Immune Regulation

    1 month ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    About the Company:DTU is a leading technical university recognized globally for academic excellence and innovation.About the Role:We are seeking an experienced research scientist to join our team at Danmarks Tekniske Universitet (DTU) as a postdoctoral researcher. The successful candidate will contribute to pioneering research within lung-to-brain...

  • Postdoc in “in vivo” Evaluation of Nanomedicines – DTU Health Tech

    1 week ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Join DTU to evaluate red blood cell substitutes using murine models. This role focuses on pioneering research in nanomedicine, specifically exploring hemoglobin-loaded nanoparticles as potential artificial blood. Candidates must have expertise in drug delivery and animal handling (mice and/or rats). The Biomimetics, Biocarriers, and Bioimplants Group (The...

  • Postdocs in Anaerobic Microbial Consortia – DTU Chemical Engineering

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    The Department of Chemical and Biochemical Engineering (DTU Chemical Engineering) invites applications for three positions as Post Doctoral Fellow to be hired for a European Research Council (ERC) funded project focusing on anaerobic microbiome for biotechnological applications aiming at valorization of biowastes. Your background is in anaerobic...

  • Postdoctoral Researcher in Lung-Brain Mast Cell Regulation

    2 weeks ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    We are seeking a talented postdoctoral researcher to join our mission to improve the lives of individuals experiencing brain fog in airway allergy and asthma.About the Project:As a postdoctoral researcher, you will have the opportunity to contribute to pioneering research within lung-to-brain immunology.You will work on a project that aims to determine the...

  • Postdoc in Modelling, control and stability assessment of converter-rich power plants in tomorr[...]

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Are you a talented, self-motivated, and team-oriented person who thrives in a collaborative environment and enjoys working with complex topics? We are looking for a postdoc to join a world-leading research environment and contribute to the development of converter-rich power plants, which are expected to play a major role in tomorrow’s power systems. You...

  • Postdoc - Modelling of flexibility from light and heavy-duty EV charging clusters and their syn[...]

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Do you want to be involved in the green energy transition? Do you wish to contribute to the development of E-mobility integration and are you looking for a career in R&D or academia? Then we have an opportunity! We invite applications for a 3-year Postdoc position that will contribute to the quantification of the flexibility from home and public charging...

  • Postdoc in Microscopy of Enzyme Immobilization – DTU Physics

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    A PostDoc position is available for experimental research on enzymes immobilized on polymeric and organic-inorganic hybrid matrices for catalysis of chemical reactions needed for transitioning to a sustainable and green society. The candidate will work on visualizing the position, density, structure, and dynamics of immobilized enzymes using a suite of...

  • Researcher in Nanomedicine Development for Blood Substitutes

    4 weeks ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    At DTU, a leading technical university globally recognized for its research excellence, you will contribute to pioneering work in nanomedicine. This position focuses on developing hemoglobin-loaded nanoparticles as potential artificial blood substitutes.We are seeking a highly motivated postdoctoral researcher with expertise in drug delivery and nanomedicine...

  • Leading Generative AI Researcher in STEM Education

    2 weeks ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    About the Position">This PhD scholarship at DTU Compute and DTU Learning Lab focuses on developing innovative Generative AI tools to enhance student learning in university STEM courses. The successful candidate will design, test, and validate these tools to provide immediate, relevant information and feedback to students' work during formative engineering...

  • Postdoc in Chemical ecology of microbial secondary metabolites

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Are you a specialist in chemical ecology, microbial natural products isolation/ characterization or the molecular characterization of the BGCs? Are you interested in the function of these metabolites in the natural (or simplified) environments? Then have a look at this position in the DTU CeMiSt center. Microbiocidal secondary (or specialised) metabolites...

  • Postdoctoral Researcher in Lung-to-Brain Immunology

    4 weeks ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    About the JobWe are seeking a highly motivated postdoctoral researcher to join our team at Danmarks Tekniske Universitet (DTU) to investigate the role of brain border mast cells and histamine in the symptoms of brain fog in airway allergy and asthma.About the ProjectThe successful candidate will contribute to pioneering research within lung-to-brain...

  • Postdoc in Electronic Corrosion Sensor Development

    1 month ago

    Kongens Lyngby, Denmark Fiskeritidende Full time

    If you are looking for an exciting opportunity for a Postdoc position, we at the Department of Civil and Mechanical Engineering, Technical University of Denmark, are seeking a candidate to work as part of the team in a project focusing on developing an integrated corrosion sensor for Electronic Corrosion monitoring. Environmental degradation of electronics...

  • Postdoc in CO2 and CO Fermentation – DTU Chemical Engineering

    4 months ago

    Kongens Lyngby, Denmark Danmarks Tekniske Universitet (DTU) Full time

    Are you a highly competent, aspiring, and thorough young scientist wanting to excel in the exciting field of gas fermentation? Then this advertisement is for you. At DTU Chemical Engineering, a postdoc position is available in the frame of research projects funded by the European Innovation Council and Novo Nordisk foundation. The postdoc project will be in...

  • Automation Expert for Microbial Cell Factory Design

    1 month ago

    Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

    About DTU BiosustainDTU Biosustain is a leading research institution in the field of microbial cell factory design. We utilize advances in automation, analytics, and data science to foster sustainable lifestyles through three application areas: Sustainable Chemicals, Natural Products, and Microbial Foods.Salary and BenefitsWe offer an attractive salary range...