Genetic Regulation Specialist

5 days ago


Copenhagen, Copenhagen, Denmark Københavns Universitet Full time

The Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR) at the University of Copenhagen is seeking a highly motivated Postdoctoral Research Fellow to join the Hansen Group. The successful candidate will work on a project that integrates high-throughput mass spectrometry-based plasma proteomics data with electronic health registry data, along with genetic information from 4,180 Greenlandic individuals.

Research Objectives

The research aims to discover novel clinical biomarkers and therapeutic targets for cardiometabolic diseases, including obesity, type 2 diabetes, and cardiovascular diseases. The Postdoc will examine baseline and longitudinal associations between the MS-based plasma proteome and cardiometabolic disease outcomes using registry-based data.

Methodology

The study involves performing genome-wide association studies (GWAS) of the MS-based plasma proteome to identify protein quantitative trait loci (pQTLs). The candidate will also examine the overlap between pQTLs and cardiometabolic disease-associated risk variants using colocalization methods.

Requirements
  • PhD in bioinformatics, computational biology, statistical genomics, or a related field.
  • Proficiency in a high-level programming language such as R or Python.
  • Experience in applying statistical methods to proteomic and/or genomic data.
  • Experience working with large genomic datasets.


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