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Postdoctoral Research Fellow in Spatial Analysis of the Tumor Microenvironment
1 month ago
The Department of Biology at the University of Copenhagen invites applications for a 2-year postdoctoral research position in spatial analysis of the tumor microenvironment. The project is part of the research project "Integrating spatial transcriptomics, live tumor microenvironment imaging and focused CRISPR screens for transformative insights in cancer biology", which is financed by a Distinguished Investigator grant from The Novo Nordisk Foundation.
Project Overview
The overall aim of the project is to establish a new way of understanding tumor biology through integrating tumor physicochemical traits and transcriptomic landscapes. The team will develop superimposed maps of key physicochemical TME parameters and cellular transcriptomes in spheroids and tumors, and combine this with 3D spheroid CRISPR screens and functional analyses to understand how cancer cells sense and react to key aspects of their environment, and to identify markers of specific physicochemical tumor traits for potential use as biomarkers and treatment targets.
Responsibilities
- Develop and perform spatial metabolomics, spatial transcriptomics, and single-cell sequencing of advanced 3D cocultures of human pancreatic cancer cells and associated stromal cells.
- Integrate these data with physicochemical parameters obtained by live imaging of pH, lactate, and oxygen.
- Use these results as the basis for initiating 3D CRISPR screens.
- Supervise a PhD student and collaborate with the research team.
Requirements
- Strong background in molecular biology and single-cell and/or spatial transcriptomics.
- Understanding of cancer biology and the tumor microenvironment.
- Experience with CRISPR screens is an advantage.
- Excellent communication and teamwork skills.
What We Offer
- A strong, highly collaborative research group with broad national and international scientific networks.
- Excellent research infrastructure and technical support.
- Highly relevant research at the crossroads between oncology, biophysics, and metabolism.
- A strong and active postdoc organization and a great scientific and social environment at the Department of Biology and the Faculty of Science.
How to Apply
The application, in English, must be submitted electronically by clicking APPLY NOW below. Please include a letter of motivation, curriculum vitae, diplomas, complete publication list, and separate reprints of 3 particularly relevant papers.
