Oral Macrocycle Discovery Specialist

4 days ago


Copenhagen, Copenhagen, Denmark The Biopôle Full time
Job Description

We are seeking a chemistry innovation lead to join our team at The Biopôle. In this role, you will be responsible for developing and executing strategies for designing orally available beyond-rule-of-5 macrocycles, working closely with our biology, DMPK, and data science teams.

Key Responsibilities
  • Design and synthesize novel therapeutics, leveraging cutting-edge chemistry and data-driven approaches.
  • Develop and implement molecular design drivers supporting medchem optimization of drug properties for oral delivery of this new class of macrocycles.
  • Act as a medchem lead and/or discovery project lead, driving cross-functional collaborations and workflow establishment.
  • Engage closely with lab-active colleagues across disciplines and sites.
Requirements
  • PhD in chemistry, pharmaceutical sciences, or a related field.
  • 10+ years of industry experience in medicinal chemistry, including hit-to-lead, lead optimization, and drug candidate selection phases.
  • Extensive experience in medicinal chemistry and drug discovery, particularly in beyond-rule-of-5 therapeutics.
  • In-depth knowledge of the drug discovery process, particularly in the context of beyond-rule-of-5 therapeutics.
  • Strong collaboration, communication, and leadership skills in a cross-functional environment.


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