Senior Biocomputational Specialist

2 weeks ago

Ballerup, Ballerup Kommune, Denmark Novo Nordisk Full time
Key Responsibilities

As a Senior Data Scientist in Antibody and VHH Design at Novo Nordisk, you will be working closely with laboratory scientists to optimize workflows that integrate bulk and single B cell sequencing from in vivo immunization with in vitro antibody and VHH library design. Your primary tasks will include:

  • Developing innovative and creative solutions to design novel antibodies or VHHs in collaboration with other departments, while supporting research projects within the antibody and VHH area.
  • Identifying potential liabilities and developability issues throughout the antibody discovery pipeline.
  • Coordinating the development of the relevant computational infrastructure for ingesting, analyzing, and exposing the information from sequencing and other data sources.
  • Utilizing existing tools or developing new ones to design and engineer antibody variants with enhanced functionality.
  • Integrating experimental results with computational models to expedite the antibody discovery process.
  • Working collaboratively with your colleagues to develop machine learning models that can be used to optimize antibody candidates.
  • Staying up to date with the latest developments in computational biology and antibody/VHH design.
  • Documenting and effectively communicating the discovery and innovation process to key stakeholders and managers.
  • Encouraging, proposing, and participating in projects boosting the use of advanced computational techniques for antibody and VHH design.


Requirements

To succeed in this role, you must:

  • Hold a Master's degree within Computational Biology, Bioinformatics, Machine Learning, or a related field.
  • Have at least 3+ years of experience in clinical or industrial antibody/VHH development.
  • Have a deep understanding of antibody or VHH sequence, structure, function, and their development in an industrial setting.
  • Previous knowledge of NGS sequencing analysis and preferably RepSeq, antibody sequencing, or TCR sequencing is a must.
  • Solid experience with relevant computational tools, including but not limited to Python programming, molecular modeling and simulations, sequence analysis, and data analysis frameworks.
  • Experience in usage of HPC solutions (AWS, Azure, or similar).
  • Full proficiency in English, with knowledge of Danish being a plus.


About the Department

The Antibody Design Department is part of the Digital Science and Innovation (DSI) area at Novo Nordisk, located in Måløv (Denmark) and London (UK). We use innovative computational tools and techniques to design novel antibodies and VHHs. Our team works collaboratively across various departments, within and outside Research and Early Development, to deliver safe and effective antibody therapies to patients. We value a diverse and inclusive culture, where our team members can thrive and grow. Our team consists of collaborative, goal-oriented individuals who take pride in their work and are committed to making a difference in patients' lives.

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