Postdoc in Enzymatic Synthesis of Human Milk Oligosaccharides

1 day ago


Kongens Lyngby, Lyngby-Tårbæk Kommune, Denmark Danmarks Tekniske Universitet (DTU) Full time

Join a research project focused on enzymatic technologies for human milk oligosaccharides (HMOs) production. Responsibilities include enzyme expression, purification, and characterization, as well as enzyme design, protein engineering, execution of activity assays, and carbohydrate analysis.
We are looking for a qualified candidate for a 2-year postdoc position that will be part of an ongoing 5-year research project. The research project is funded by the Innovation Fund Denmark and is a collaboration between the Technical University of Denmark (DTU), University of Copenhagen (KU), and DSM-Firmenich (Hørsholm, DK). The project seeks to develop new enzymatic technologies for production of human milk oligosaccharides (HMOs) and involves enzyme discovery, enzyme expression and characterization, enzyme design and protein engineering to obtain HMOs. If you are seeking to establish your career as a top-level scientist whose results have impact for human health and nutrition, this postdoc provides a strong foundation for fulfilling this ambition.

Responsibilities and qualifications
Within the larger research project, the postdoc will be responsible for defined parts of enzyme expression, purification, and characterization, as well as for design and execution of enzyme activity assays. The optimal candidate will be involved in enzyme discovery/selection as well as protein design and engineering targeting enzymatic synthesis of specific HMO carbohydrate structures. The job involves close collaboration with industry and includes extensive collaboration within the project research group. The latter includes training of new group members and visitors in relevant laboratory technologies as well as supervision of selected BSc and MSc students.

As a formal qualification, you must hold a PhD degree (or equivalent). The PhD degree must be in biotechnology, biochemistry, enzyme technology, or another discipline relevant for enzymatic carbohydrate synthesis. In addition, required qualifications are:

  • Documented theoretical and practical experience in protein expression, enzyme purification and characterization
  • Documented theoretical and practical experience in design and execution of enzyme activity assays
  • Innovative, independent research capability and good problem-solving skills
  • A track record of publication with at least two first-author papers within the field of enzyme technology and/or carbohydrate enzymology in internationally recognized, peer-reviewed journals
  • Excellent communication skills in English (written and spoken)
  • Strong interpersonal communication skills, exceptional reliability, and a team-work mentality.

In addition, the optimal candidate has practical experience in one or more of the following fields:

  • Computational studies of enzyme structure-function relationships
  • Enzyme design to obtain new specificities and/or improved activities
  • Enzyme discovery
  • Carbohydrate analysis by HPAEC-PAD and/or LC-ESI-MS.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 2 years (24 months). The starting date is November 1st, 2024 (or according to mutual agreement).

You can read more about career paths at DTU here.
Further information
Further information may be obtained from Assistant Professor Birgitte Zeuner ( ) or Professor Anne S. Meyer ( ).

You can read more about DTU Bioengineering at

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 11 September 2024 (23:59 Danish time) .

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file . The file must include:

  • Application (cover letter)
  • CV
  • Academic Diplomas (MSc/PhD – in English)
  • List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science- and biotech industries and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN's 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

Adresse:

Søltofts Plads
2800 Kgs. Lyngby

#J-18808-Ljbffr

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