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PhD Fellowship to Study Metabolic Control of Genome Integrity and DNA Replication in Early Development Mechanism and Cancer
2 months ago
We are seeking a highly motivated PhD student to join our research group at Syddansk Universitet. The successful candidate will be working on a project focused on the metabolic control of genome integrity and DNA replication in early development mechanisms and cancer.
Research ProjectThe project aims to uncover the regulatory foundations of human DNA replication and genome protection by investigating how active reorganization of the replisome motor is achieved in response to natural fluctuations in metabolic pathways inevitable during early development and cancer.
Responsibilities- Conduct advanced quantitative cell biology approaches such as quantitative-image-based-cytometry- QIBC, time-lapse microscopy, super-resolution microscopy, DNA fiber techniques, with classical genetics and biochemistry to reveal novel regulations of replisome velocity and identify how cancer-specific metabolic changes impact DNA replication speed, replisome integrity and cell cycle in human cells.
- Interact and collaborate closely with other researchers in the research group and with members of the different research groups within the Department of Biochemistry and Molecular Biology.
- A master's degree in Life Science, preferably Molecular Biology, Cell Biology, Biomedicine (the 5+3 programme). Candidates who, in addition to their bachelor's degree, have passed 60 ECTS of their master's programme by 1 September 1 2024, are invited to apply for a PhD scholarship within the 4+4 programme.
- Curious mind-set with a strong interest in fundamental Cell cycle, DNA replication and Genome integrity.
- Relevant laboratory experience in molecular cell biology and biochemistry.
- Know-how in Genome integrity field, stem cell culture, light microscopy, bioinformatics.
- Strong communication and collaborative skills and an interest in working in an interdisciplinary environment.
- Proficiency in spoken and written English.
A 5+3 PhD programme spans over three years (fully salaried), while the 4+4 programme runs for a period of four years. If enrolled in the 4+4 programme, your will be enrolled in the PhD programme and the master's programme parallel to each other. During this period, the pay will consist of the Danish Student Allowance (SU), if you are eligible, and a supplementary salary for job assignments. After completing the master's degree, you will enter a fully salaried PhD scholarship for the remaining two years.
